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        Herbal Formulary 


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La Larria Botanicals

       MindCare Medic

​ Everyday neuroprotection


MindCare Medic is a combination of:  Salvia miltiorrhiza root, Gotu Kola leaf, Gingko biloba leaf, Valeriana wallichii root and St. John’s wort tops and flowers, alcohol and distilled water.

Below is detailed information on each Herb and gives information on why each of these important Herbs are used in this medic tincture formulation.  My Medic Tinctures are designed to be taken daily and in this case to be used as a neuroprotective agent.  

If you don’t want to read all the information, the most relevant is in the first paragraph below each herb.


About Salvia miltiorrhiza
Salvia miltiorrhiza is among the most popular medicinal herbs used in China. It has been used in the treatment of stroke since 1970 , angina and heart attack, as an antihypertensive and a sedative . S. miltiorrhiza contains several compounds that are pharmacologically active, especially the diterpenoids known as tanshinones. This herb is used to treat deficiency of qi and some other conditions. Qi is the life force that comes from air, food and the genetic background. The therapeutic principle of the treatment is to supplement qi, nourish the blood and promote blood circulation in order to remove obstructions of the channels, which are the acupuncture channels, not blood vessels.   The active compounds, tanshinones and salvianolic acids, have anticoagulant, vasodilatory, increased blood flow, anti-inflammatory, free radical scavenging, and mitochondrial protective. 

Research on Salvia miltiorrhiza
Ameliorating effects of compounds derived from Salvia miltiorrhiza root extract on microcirculatory disturbance and target organ injury by ischemia and reperfusion

Abstract
Ischemia and reperfusion (I/R) exerts multiple insults in microcirculation, frequently accompanied by endothelial cell injury, enhanced adhesion of leukocytes, macromolecular efflux, production of oxygen free radicals, and mast cell degranulation. Since the microcirculatory disturbance results in injury of organ involved, protection of organ after I/R is of great importance in clinic. Salvia miltiorrhiza root has long been used in Asian countries for clinical treatment of various microcirculatory disturbance-related diseases. This herbal drug contains many active water-soluble compounds, including protocatechuic aldehyde (PAl), 3,4-dihydroxyphenyl lactic acid (DLA) and salvianolic acid B (SalB). These compounds, as well as water-soluble fraction of S. miltiorrhiza root extract (SMRE), have an ability to scavenge peroxides and are able to inhibit the expression of adhesion molecules in vascular endothelium and leukocytes. Moreover, lipophilic compounds of SMRE also prevent the development of vascular damage; NADPH oxidase and platelet aggregation are inhibited by tanshinone IIA and tanshinone IIB, respectively, and the mast cell degranulation is blunted by cryptotanshinone and 15,16-dihydrotanshinone I. Thus, the water-soluble and lipophilic compounds of SMRE appear to improve the I/R-induced vascular damage multifactorially and synergically.

About Gotu kola (Centella asiatica)
Gotu kola (C.A.) on relieving anxiety and improving cognition.C. asiatica (gotu kola) is a reputed plant species for its traditional use in ayurvedic and Chinese medicines [52], and its positive effects on brain aging have been generally attributed to its two major triterpene saponosides; asiatic and madecassic acids as well as their heterosides; asiaticoside and madecassoside, respectively. 

In addition to neuroprotective effect of C. asiatica, it has been reported to own a wide range of biological activities desired for human health such as wound healing [5–7], anti-inflammatory [8, 9], antipsoriatic [10], antiulcer [11, 12], hepatoprotective [13], anticonvulsant [14], sedative [15], immunostimulant [16], cardioprotective [17, 18], antidiabetic [19], cytotoxic and antitumor [20, 21], antiviral [22], antibacterial [23], insecticidal [24], antifungal [25], antioxidant [26–28], and for lepra [29] and venous deficiency treatments [30, 31].

Amyloidosis, oxidative stress and inflammation have been strongly implicated in neurodegenerative disorders like Alzheimer's disease. Traditionally, Gotu kola, Centella asiatica leaf extracts are used to treat brain related diseases in India.  C. asiatica is reported to be used to enhance memory and to treat dementia.

Research on Gotu kola
Emerging role of Centella asiatica, (Gotu Kola) in improving age-related neurological antioxidant status.
Abstract

Free radicals have been hypothesized to play an important role in ageing process. There exists an imbalance between free radical production and antioxidant defense mechanism, which may lead to cell death during ageing. Our study was designed to determine whether extract of Centella asiatica, an antioxidant, when administered orally (300 mg/kg body weight/day) for 60 days would prevent age-related changes in antioxidant defense system, lipid peroxidation (LPO) and protein carbonyl (PCO) content in rat brain regions such as cortex, hypothalamus, striatum, cerebellum and hippocampus. Aged rats elicited a significant decline in the antioxidant status and increased the LPO and PCO as compared to control rats in all five regions studied. The increase in LPO and PCO contents were (64%, 34%) in cortex, (86%, 30%) in cerebellum, (51%, 47%) in striatum, (77%, 27%) in hypothalamus and (58%, 45%) in hippocampus, respectively, in aged rats as compared to young rats. Supplementation of C. asiatica was effective in reducing brain regional LPO and PCO levels and in increasing the antioxidant status. Thus, C. asiatica by acting as a potent antioxidant exerted significant neuroprotective effect and proved efficacious in protecting rat brain against age related oxidative damage.

Comparative study on anti-oxidant and anti-inflammatory activities of Caesalpinia crista and Centella asiatica leaf extracts.
In vitro evidence that an aqueous extract of Centella asiatica, (Gotu kola) modulates α-synuclein aggregation dynamics.
Abstract

The aqueous extract of Centella asiatica (CA) is traditionally used as a brain tonic and CA is known to improve cognition and memory. There are limited data on the role of CA in modulating amyloid-β (Aβ) levels in the brain and in Aβ aggregation. Our study focuses on CA as a modulator of the α-synuclein aggregation pattern in vitro. The results showed that the CA aqueous extract completely inhibited the α-synuclein aggregation from monomers. Further, CA extract significantly inhibited the formation of oligomer to aggregates and favored the disintegration of the preformed fibrils. The study provides an insight in finding new natural products for future PD therapeutics.C.A.   neuroprotective activity of Centella asiatica (L.) Urban, also known as "Gotu Kola." The plant is native to the Southeast Asia and has been used traditionally as brain tonic in ayurvedic medicine.

C. asiatica (gotu kola) has been reported to have a comprehensive neuroprotection by different modes of action such as enzyme inhibition, prevention of amyloid plaque formation in Alzheimer's disease, dopamine neurotoxicity in Parkinson's disease, and decreasing oxidative stress. Therefore, C. asiatica could be suggested to be a desired phytopharmaceutical with neuroprotective effect emerged from traditional medicine.

Valeriana wallichii, jatamansi root
Both Valerian wallichii and officinalis are useful as natural relaxants. They are effective for quieting an overactive mind, valerian has played the role of a natural sedative for millennia. Valerian species have been valued for their calming influence by healers in Asia, Europe, and North America. Dozens of modern studies have confirmed that this strong-smelling herb has measurable tranquilizing properties with minimal side effects.  The difference between Valeriana wallichii and Valeriana officinalis is that Valeriana wallichii is not as hypnotic and the sedative effects can more easily be controlled and is more associated with mental clarity, than it’s sedative abilities.

Valerian wallichii is native to India (Himalayas) and is found to occur between 3,300 and 6,000 m in the Himalayas: Kashmir (India), Uttar Pradesh (India), Nepal, Sikkim (India), Bhutan, South-West China including Tibet, Yunnan and southwest Sichuan. In nature, the plant is generally found clinging to steep rocky cliffs, stony and grassy slopes, and is rarely found as lithophytes. It is also reported from ravines of the rocks and crevices, small depressions, somewhat found in wet meadows and by the banks of the rivulets in the high valleys and peaks ranging from 3,000 - 4,000 m.Indian valerian is used in various pharmaceutical preparations for the treatment of migraine. The active constituent if the root of valeriana wallichii is valerenic acid, valerenol, valerenone, valtrate, Isovaltrate.

The plant has a rich history of medicinal use and has been valued for centuries in Ayurvedic (Indian) and Unani (ancient Greco-Arab) systems of medicine.  Valeriana wallichii has been utilized since ancient times as a medicine for curing heart diseases, mental retardation, urine-related problems, insomnia etc. Famed Ayurvedic-healer Charaka and "Father of Surgery" Sushruta incorporated Jatamansi in many medicinal oils, which are prescribed for edema, hemorrhoids, arthritis, gout, fractures, and obstinate skin diseases. The root has been medically used to treat insomnia and blood, circulatory, and mental disorders. Some preparations of the plant have been used as a heptotonic, cardiotonic, analgesic, and diuretic in the Unani system of medicine.

Research on Valeriana wallichii
ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC AND AQUEOUS EXTRACTS OF VALERIANA WALLICHII DC RHIZOME  Fazal Subhan1, Nasiara Karim1, Muhammad Ibrar2 1 Department of Pharmacy, University of Peshawar, Peshawar 2 Department of Botany, University of Peshawar, Peshawar 

Abstract 
 
Valeriana wallichii DC (Valerianaceae) is an indigenous medicinal plant used in ethno medicine for the treatment of habitual constipation, insomnia, epilepsy, neurosis, anxiety and as a diuretic, hepatoprotective, analgesic and cytotoxic. The aqueous extract (Aq.Ext) and methanolic extract (Me.Ext) were subjected to anti-inflammatory activity using experimental animal model of carrageenan induced paw oedema in the presence of control for comparison. The results showed that both Aq and Me extracts significantly ameliorate oedema comparable to reference standard, aspirin. The results of this study explicate justification of the use of this plant in the treatment of inflammatory disease conditions.

Valeriana wallichii showed anti-inflammatory properties, similar to those observed for non-steroidal anti inflammatory drugs, such as aspirin. It is also suggested that the mechanism of action of Valeriana wallichii might be associated with the inhibition of histamine, serotonin and prostaglandins synthesis

St. John’s wort
St. John’s Wort (SJW), known botanically as Hypericum perforatum, is a sprawling, leafy herb that grows in open, disturbed areas throughout much of the world’s temperate regions. The use of this species as an herbal remedy to treat a variety of internal and external ailments dates back to the time of the ancient Greeks. Since then, it has remained a popular treatment for anxiety, depression, cuts, and burns. The extract I make is from fresh tops and flowers, which are sent to me overnight so that I can tincture them the day after they are harvested.  This yield the best most efficacious tincture.
Recent research suggests the effectiveness of this herb in treating other ailments, including cancer, inflammation-related disorders, and bacterial and viral diseases, and as an antioxidant and neuroprotective agent. 

Pharmaceutical companies, particularly in Europe, prepare standard formulations of this herb that are taken by millions of people as a substitute for Prozac.   SJW produces dozens of biologically active substances, although two—hypericin (a naphthodianthrone) and hyperforin (a lipophilic phloroglucinol)—have the greatest medical activity. 

Other compounds, including the flavonoids rutin, quercetin, and kaempferol, also appear to have medical activity. H. perforatum has been intensively studied on isolated tissue samples, using animal models and through human clinical trials. The effectiveness of SJW as an antidepression agent is particularly well studied, and the underlying mechanisms are well understood.

Ginkgo biloba
Ginkgo (Ginkgo biloba) is one of the oldest living tree species.. In Europe and the United States, ginkgo supplements are among the best-selling herbal medications.

Ginkgo has a long history of being used in traditional medicine to treat blood disorders and improve memory, and it's best known today as way to potentially keep your memory sharp. There is some scientific evidence to back that up. Laboratory studies have shown that ginkgo improves blood circulation by opening up blood vessels and making blood less sticky. It's also an antioxidant.   Gingko crosses the blood brain barrio making it especially effective in neurologic diseases.

For those reasons, ginkgo may improve vein and eye health. Although not all studies agree, ginkgo may help treat dementia (including Alzheimer's disease) and intermittent claudication, or poor circulation in the legs. It may also protect memory in older adults.

Ginkgo leaves have two types of chemicals (flavonoids and terpenoids) that are antioxidants. In your body, harmful particles called free radicals build up as you age, and may contribute to heart disease, cancer, and Alzheimer's disease. Antioxidants like those found in ginkgo fight off free radicals, and stop them from damaging DNA and other cells.

Plant Description
Ginkgo biloba is the oldest living tree species. A single tree can live as long as 1,000 years and grow to a height of 120 feet. It has short branches with fan-shaped leaves and inedible fruits that smell bad. The fruit has an inner seed, which may be poisonous. Ginkgos are tough, hardy trees and are sometimes planted along urban streets in the United States. The leaves turn brilliant colors in the fall.

Research on Ginkgo biloba 
Age-associated memory impairment Age-associated memory impairment (AAMI) is a nonspecific syndrome, which may be caused by early Alzheimer's disease or multi-infarct dementia.

Cerebral insufficiency (insufficient blood flow to the brain)  Cerebral insufficiency is characterized by poor concentration, confusion, decreased physical performance, fatigue, headache, dizziness, depression, and anxiety. Research of ginkgo for cerebral insufficiency has demonstrated efficacy in reducing symptoms.

Dementia Overall, the scientific literature suggests that ginkgo benefits people with dementia. Ginkgo may improve cognitive performance and protect against Alzheimer's. However, conclusions regarding ginkgo for dementia are often conflicting. Additional research is needed in this area.

Generalized anxiety disorder From available research, ginkgo offers benefit to people with generalized anxiety disorder (GAD).

Schizophrenia Research suggests that in combination with antipsychotics, ginkgo may offer benefits for people with schizophrenia. Additional research is needed on this topic

Altitude (mountain) sickness Research on ginkgo for the treatment of altitude (mountain) sickness reports conflicting results.

Attention-deficit hyperactivity disorder (ADHD) Limited research suggests that ginkgo is less effective than methylphenidate for symptoms of ADHD. Studies using combination therapies with ginkgo suggest benefits for ADHD symptoms. Further research on ginkgo alone is needed on this topic.

Chronic venous insufficiency (damaged vein valves) Ginkgo may widen and relax blood vessels. A combination product containing ginkgo may aid in treating people with lower limb chronic venous insufficiency.

Claudication (painful legs from clogged arteries) Ginkgo may improve claudication symptoms. However, improvements in the absolute claudication distance were lacking in some studies

Cognitive performance According to limited research, ginkgo may improve cognitive function in people with multiple sclerosis (MS) and vascular cognitive impairment no dementia (VCIND).

Diabetic nephropathy (kidney disease) The effect of ginkgo has been studied on various endpoints in people with diabetic nephropathy. Benefits were observed in parameters of kidney function.

Dyslexia Ginkgo is traditionally used for improved memory or cognition. Preliminary results suggest that Ginkgo may be of benefit for dyslexia.

Fibromyalgia (nervous system disorder) CoQ10 and ginkgo improved quality of life and self-rating scores in people with fibromyalgia.

Hearing loss In individuals with hearing loss, a higher dose of ginkgo was more effective than a lower ginkgo dose. Ginkgo may decrease the ear inflammation and improve hearing.

Heart disease Ginkgo may have positive benefits on blood flow and relax blood vessels

Macular degeneration (eye disease) Preliminary research suggests that ginkgo may have antioxidant effects and improve eye blood flow.

Migraine Various trials have examined the effects of ginkgo as part of migraine treatment. Overall, these studies suggest an evidence of benefit in children and women.Mood and cognition in post-menopausal womenIn early research, ginkgo appeared to have modest beneficial effects on mood and cognition in postmenopausal women.

Multiple sclerosis Ginkgo's anti-inflammatory and platelet-activating factor (PAF)-inhibiting properties may help treat multiple sclerosis (MS).

Pulmonary interstitial fibrosis (scarred lung tissue) In early research, ginkgo was found to be effective in treating pulmonary interstitial fibrosis.

Quality of life A few studies have suggested that Ginkgo may aid in quality of life

Retinopathy (eye damage from type 2 diabetes) Early research suggests that ginkgo extract benefit to people with retinopathy.

Stroke recovery Laboratory studies suggest that ginkgo may be helpful immediately following strokes, because of possible antioxidant or blood vessel effects.

Raynaud's disease (poor circulation) Limited research suggests that ginkgo may be effective in reducing the number of attacks in people with Raynaud's disease (RD).

 ​MindCare Medic:  30ml,  $12.00