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La Larria Botanicals
An Everyday Treatment to Calm the Hypertensive
Formulation of HeartCare Medic
Organic Hawthorn berry (Ceataegus lavigata)
Organic Hawthorn tops
Organic Salvia miltiorrhiza root
Wildcrafted Salvia columbariae root
55 % Alcohol
HeartCare Medic Actions
Actions: Cardiotonic, vascular tonic, hypotensive, diuretic and astringent. A specific whole plant remedy (tops & berries) for most cardiovascular diseases to improve coronary circulation, reduces angina attacks by dilating coronary arteries. It enhances cardiac muscle cellular metabolism, cellular energy management and cardiac contraction. Hawthorn is a cardiotonic plant with observed benefical actions on heart and blood vessels which do not contain cardiac glycosides.
Hawthorn contains: flavonoids, vitexin, quercetin, hyperoside, cyaidins, triterpens and phenolic acids. Medical indications include essential hypertension, improved recovery after myocardial infraction, coronary artery disease and is especially useful as a long tern tonic for the aging heart.
Typical tonic dose is 2 1/2ml 3x/day and as a medicinal dose of 5ml 3x/day. Hawthorn may be taken over long periods of time, as there is little risk of toxicity.
About Salvia miltiorrhiza and Salvia columbariae.
The information below is about the effects the two Salvia’s for both heart disease and stroke as it is used in China. Salvia miltiorrhiza is among the most popular medicinal herbs used in China. It has been used in the treatment of stroke since 1970 , angina and heart attack, as an antihypertensive and a sedative .
S. miltiorrhiza contains several compounds that are pharmacologically active, especially the diterpenoids known as tanshinones. This herb is used to treat deficiency of qi and some other conditions. Qi is the life force that comes from air, food and the genetic background. The therapeutic principle of the treatment is to supplement qi, nourish the blood and promote blood circulation in order to remove obstructions of the channels, which are the acupuncture channels, not blood vessels. Huangqi is Astragalus membranaceus contains astragaloside IV that is neuroprotective in a stroke model [62,63]. It is also used to reestablish qi.
The active compounds, tanshinones and salvianolic acids, have anticoagulant, vasodilatory, increased blood flow, anti-inflammatory, free radical scavenging, and mitochondrial protective.
A related plant, Salvia columbariae, from California also contains tanshinones, especially crypto tanshinone. This plant has been used by Californian Indians to treat people suffering from strokes. This plant is not commercially available and is wildcrafted in the Mojave desert witch the goal to establish a small plantation.
Research on Salvia miltiorrhiza
Ameliorating effects of compounds derived from Salvia miltiorrhiza root extract on microcirculatory disturbance and target organ injury by ischemia and reperfusion
Abstract: Ischemia and reperfusion (I/R) exerts multiple insults in microcirculation, frequently accompanied by endothelial cell injury, enhanced adhesion of leukocytes, macromolecular efflux, production of oxygen free radicals, and mast cell degranulation. Since the microcirculatory disturbance results in injury of organ involved, protection of organ after I/R is of great importance in clinic.
Salvia miltiorrhiza root has long been used in Asian countries for clinical treatment of various microcirculatory disturbance-related diseases. This herbal drug contains many active water-soluble compounds, including protocatechuic aldehyde (PAl), 3,4-dihydroxyphenyl lactic acid (DLA) and salvianolic acid B (SalB). These compounds, as well as water-soluble fraction of S. miltiorrhiza root extract (SMRE), have an ability to scavenge peroxides and are able to inhibit the expression of adhesion molecules in vascular endothelium and leukocytes.
Moreover, lipophilic compounds of SMRE also prevent the development of vascular damage; NADPH oxidase and platelet aggregation are inhibited by tanshinone IIA and tanshinone IIB, respectively, and the mast cell degranulation is blunted by cryptotanshinone and 15,16-dihydrotanshinone I. Thus, the water-soluble and lipophilic compounds of SMRE appear to improve the I/R-induced vascular damage multifactorially and synergically.
Neuroprotective effects of tanshinones in transient focal cerebral ischemia in mice
Summary: Tanshinones are the major lipid soluble pharmacological constituents of Danshen, the dried roots of Salvia miltiorrhiza Bunge (Labiatae), a well known traditional Chinese medicine used for the treatment of cerebrovascular diseases including stroke. Potential neuroprotective effects of tanshinones IIA (TsIIA) and IIB (TsIIB) were examined in adult mice subjected to transient focal cerebral ischemia caused by middle cerebral artery occlusion (MCAo).
Our results revealed that TsIIA (16 mg/kg) readily penetrated the blood brain barrier reaching a peak concentration of 0.41 nmol/g brain wet weight 60 minutes after intraperitoneal injection and decreased slowly over several hours. Twenty-four hours after middle cerebral artery occlusion, brain infarct volume was reduced by 30% and 37% following treatment with TsIIA and TsIIB, respectively. The reduction in brain infarct volume was accompanied by a significant decrease in the observed neurological deficit. Tanshinones or other structurally related compounds may have potential for further development as neuroprotective drugs.
Preclinical and clinical examinations of Salvia miltiorrhiza and its tanshinones in ischemic conditions
Brain ischemia and reperfusion, during stroke, cause the release of many neurotransmitters including norepinephrine, in part due to ATP depletion. These neurotransmitters may be damaging to the brain by inducing excitotoxicity, by oxidizing to produce oxygen radicals or other mechanisms. The effects of angiotensin on extracellular neurotransmitter levels during ischemia and reperfusion in the brain could be devastating. S. miltiorrhiza has been shown to decrease the release of norepinephrine, dopamine and serotonin during brain ischemia .
S. miltiorrhiza has other effects on stroke including anti-inflammation, free radical scavenging, antioxidant and mitochondrial protection effects. Tanshinone I from S. miltiorrhiza inhibits arachidonic acid metabolism, interleukin-12 production and has anti-inflammatory effects [21,22]. Neutrophil activation is inhibited by an unspecified tanshinone  which is an anti-inflammatory agent. S. miltiorrhiza antioxidant activity is also expressed as increases in superoxide dismutase, catalase, glutathione peroxidase and glutathione transferase activities [24,25]. Free radical scavenging and mitochondrial protective activities of S. miltiorrhiza have been found [26-28].
Kang et al.  investigated the effects of tanshinones on the production of interleukin-12 (IL-12) and interferon-gamma (IFN-γ), cytokines playing important roles in mediating T and natural killer (NK) cell functions. They found that all tested tanshinones (TI, CT and DH-TI) at sub- and low micromalor levels inhibited IL-12 production in lipopolysaccharide (LPS)-activated mouse macrophages in a concentration-dependent manner. Taken together, these limited data suggest a possible role of tanshinones in regulating inflammatory and immune responses.
Why these Herbs?
Hawthorn berry & tops: Cardiotonic, Vascular Tonic
Salvia miltiorrhiza: Cardiotonic, hypotensive Can be taken safely over long periods of time.